- 期刊
The Effect of Omeprazole on Twenty-Four Hour Intragastric Acidity in Duodenal Ulcer Patients
口服omeprazole對十二指腸潰瘍病患二十四小時胃內酸度之影響
摘要
本研究採用放置於胃上部之銻質微電極連續錄取pH值並記錄於攜帶型胃酸記錄儀。十二位十二指腸潰瘍病患於服用omeprazole 20 mg前一天，服藥後第一天，及連續投藥七天後，利用上述方法測定24小時胃酸pH值，結果12位病患服藥前一天的平均24小時pH中間值為1.38±0.34，經口服用Omeprazole 20 mg一天後，上升至3.13±2.32 (p=0.0033)，連續服用七天後，上升至5.25±2.29 (p=0.0281)，個別病患，對服用藥物後之胃酸分泌差異頗大，尤其是經服用第一劑後的個別差異更為顯著，其中五位平均胃酸抑制達99.91±0.09%。其餘七位的胃酸被抑制程度從0~63%不等，平均為30.6±25.1%；經過服藥七天後，發現二位病患對藥物仍無反應，其餘則反應良好。此外，年紀越大，對藥物反應越良好(p=0.029).
並列摘要
Intragastric acidity over a 24-hour period was measured continuously by ambulatory acidity monitors in 12 patients with duodenal ulcers. An intragastric antimony electrode was placed 5 cm past the EC junction, and the pH was recorded with a portable pH module and data collection unit. Intra gastric acidity was measured before and after treatment with 20 mg of oral omeprazole daily, for first 1 and then 7 doses. The mean baseline 24-hour median pH of the patients was raised from 1.38±.34 to 3.13±2.32 after 1 dose of 20 mg of omeprazole (p=0.0033). After 7 doses, the mean 24-hour median pH was raised to 5.25±2.29 (p=0.0281). A wide variation in response of individuals was observed, especially after only 1 dose. Five patients showed marked acid suppression (mean±STD=99.91±0.09%), while 7 patients showed percentages of acid suppression of 0~63%. (mean±STD=30.6%±25.1%). After 7 treatment doses, 2 non-responders were noted. A higher percentage of acid suppression was also found in older patients (p=0.029).