Most studies on exercise physiology used males as subjects. The results may not be applicable to females because of the more complicated physiological and hormonal responses than males. In this article, we investigated the gender difference in muscular fatigue and the possible mechanisms responsible for the difference. Most studies suggested that, in repetitive muscular contraction at low to moderate intensities, females showed higher resistance of muscular fatigue than males The gender difference disappeared when the contraction intensities reached near or at the maximum voluntary contraction The possible mechanisms for the gender difference may include: (1) lower metabolic load in female muscles, (2) females produced higher percentage of energy aerobical1y H and (3) gender difference in neuromuscular activities