Streptococcus pneumoniae are common inhabitants of the respiratory tract and can cause many diseases, including otitis media, sinusitis, and pneumonia. S. pneumoniae also causes invasive pneumococcal disease, especially in high-risk groups. Vaccines are considered the most effective way to prevent pneumococcal infection. Currently available in Taiwan are 1 pneumococcal polysaccharide vaccines, PPV 23, and 2 pneumococcal conjugate vaccine, PCV13 and PCV15 for prevent disease. High-risk groups can follow the Vaccine Recommendations by Taiwan CDC to get protection from pneumococcal infections. S. pneumoniae is the most identified pathogen in secondary bacterial infection patients following a primary influenza virus infection. As a result, annual influenza vaccination is also an important preventive method.