- 期刊
合併使用銀杏與阿斯匹靈的自發性口腔黏膜下出血－病例報告
Spontaneous Oral Submucosa Bleeding Caused by Combination Use of Ginkgo Biloba and Aspirin - A Case Report
摘要
銀杏產品種類繁多，包括保健食品、保健藥品、及處方用藥，由大量產品廣告可知使用民眾很多。銀杏與許多藥物產生交互作用，其中與非類固醇抗炎藥物（NSAIDs）、抗凝血劑 ，併發的不正常出血更引起關注。本病例報告為一79歲女性，合併使用銀杏製劑及低劑量阿斯匹靈（100mg/日），產生左側顏面自發性口腔黏膜下出血。經病史及藥史回顧後，病患服用銀杏製劑及低劑量阿斯匹靈，血液檢查顯示出血時間為正常值2.3倍。病患經1週停藥後，血液檢查恢復正常；2週後外觀恢復正常。非類固醇抗炎藥物（NSAIDs）是牙科臨床治療經常使用的止痛劑，銀杏萃取物等相關產品廣為中老年人使用，就診時應仔細詢問，避免自發性出血，及降低嚴重術後出血風險。
並列摘要
There are a variety of Ginkgo biloba products available, including health foods, supplements and prescription medicine. Ginkgo biloba is widely advertised, and therefore, it’s commonly used and seen in practice. However Ginkgo biloba’s various interactions with specific medicines, such as nonsteroid anti-inflammatory drugs (NSAIDs) or anticoagulants, and produce significant abnormal bleeding. On review, most of these abnormal bleeding cases were cerebral bleeding or eye bleeding. This is a case report of a 79-year-old female, who took Ginkgo product as supplement and low dose aspirin (100mg /per day), with spontaneous submucosa bleeding on her left cheek area. After reviewing the patient’s medical and medicine history, both aspirin and Gingko were suspended. A laboratory test revealed that prolonged bleeding time was 2.3 times the normal period. After ceasing aspirin and Gingko, the bleeding time returned to normal one week later, and the patient regained her usual appearance two weeks later.Nonsteroid anti-inflammatory drugs are the most widely used pain controllers in dental field. Ginko biloba products are also commonly consumed by elderly patients. To avoid the risk of spontaneous bleeding and postoperative bleeding, it is important to review patient‘s herbal medicine history and medical history in advance.