本文探討反式-(3-苯基乙醯胺基)-4-苯基含磺酸基β-內醯胺之合成,該類化合物屬aztreonam抗生素之新類型衍生物。利用還原及醯化反應,可成功地將三氮官能基經一步反應直接轉換為醯胺官能基。
Synthesis of trans-(3-phenylacetamido)-4-phenyl monobactamic acid is described. This compound is a new analogue of aztreonam antibiotic. A one-pot reaction, involving reduction and acylation, was also developed for the transformation of the azide functionality to the amide group.