兒童之胎兒性紅血球及血紅素量及換血治療之影響

Summary in English Fetal Erythrocytes and Hemoglobin in Infants and Children-Influence of Exchange Transfusion

錢光新(Kouang-Sing Ts'ien)

《Acta Paediatrica Sinica》 4卷3期 (1963/09) Pp. 169-175

摘要

為觀察兒童出生後產生胎兒性血紅素之情況，作者曾以Kleihauer之血液塗片法觀察187個六歲以下之兒童及9個受換血治療之新生兒，並以鹼性變性法觀察99個六歲以下之兒童。以Kleihauer之血液塗片法和鹼性變性法所作之檢驗皆顯示兒童於出生後仍繼續產生胎兒性血紅素。但其量則因年齡之增加而減少。
以鹼性變性法所作之檢驗顯示約於3歲時兒童之胎兒性血紅素已降至成人量而以Kleihauer法之檢驗則表示兒童直至6歲時其所產生之胎兒性紅血球仍常超成人量。
於出生2月前，Kleihauer法所得之胎兒性紅血球比例常超過鹼性變性法所得之胎兒性血素比例，於2月後則相反，Kleihauer法之結果常低於鹼性變性法之結果。此可能因胎兒性紅血球多少含有成人性血紅素而中間性及成人性紅血球亦多少含有胎兒性血紅素所致。
換血前後以Kleihauer法所作之檢驗更明顯表示新生兒於出生後仍繼續產生胎兒性紅血球。

並列摘要

Fetal Erythrocytes and Hemoglobin in Infants and Children Influence of Exchange Transfusion by
In order to understand the developmental patterns of fetal erythrocytes and hemoglobin after birth, the author studied 187 children under 6 years of age and 9 newborns treated with exchange transfusion by Kleihauer's acid elution method for estimation of fetal erythrocytes and by the modified Singer's alkaline denaturation method for determination of fetal hemoglobin. The results were expressed as percentage to total erythrocytes and hemoglobin, respectively.
Results obtained from this study showed that fetal hemoglobin gradually decreased to the adult level at about 3 years of age, whereas fetal erythrocytes in children were higher than that in adults even at the age of 6 years.
Before the age of 2 months, the fetal erythrocyte level in percentage was higher than that of fetal hemoglobin but beyond
this age the former lower than the latter. The results suggested both fetal and adulterythrocyte may contain a mixture of fetal and adult hemoglobin.
Results obtained before and after exchange transfusion clearly demonstrated that infants continued to produce fetal hemoglobin even after birth though at a rapidly declining rate.
Acknowledgments:
This study was done during the author's stay at the Hospital ”Centre de Pediatrie War Memorial, Bruxelles”. The author is grateful to Dr. M. Lust, Chief of the hospital for his kind guidance and encouragement, Drs. M. Martin, R. Blanco and Miss J. Kint for their precious assistance in this study. Acknowledgement is also made with thanks to Prof. H. Y. Wei and Prof. T. C. Le e for reading and invaluable criticism of the manuscript.