新生兒高血清膽紅素症之追蹤研究

Follow Up Study Neonatal Hyperbilirubnemia

王啓祥(Chi-Shiang Wang)

《Acta Paediatrica Sinica》 7卷2期 (1966/06) Pp. 78-89

並列摘要

The results of follow up studies of 75 cases of neonatal hyperbilirubinemia are presented. Of the 75 cases 42 were admitted to the Pediatric Ward of National Taiwan University Hospital during the period of January 1959-December 1963, and 33 were born at the National Taiwan University Hospital during the period of January-December 1963. They were foll-owed up for from 1 year and 11 months to 6 years and 8 months.
1. Of 75 cases 22 suffered from kernicterus. The diagnoses were made before discharge from the hospital in 19 cases, and at follow up in 3 cases.
2. The possible causes related to hyperbilirubinemia were: severe infection in 23, G-6-P D deficiency in 2, G-6-P D deficiency complicated with severe infection in 2, Rh incompatibility in 7, use of vitamin K in 1, perinatal distress in 6, prematurity in 4, and undetermined in 29 (some may be related to breast feeding).
3. Relationship between the peak serum total bilirubin concentration and the occurrence of kernicterus is as follows: Kernicterus developed in all 9 cases (100%) with total bilirubin over 35mg %, in 7 of 11 (63.7%.) with total bilirubin at 30-35mg%, in 5 of 13 (38.5%) with total bilirubin at 25-30mg%, and only in one of 42 (2.38%) with total bilirubin below 25mg%.
4. In this series kernicterus developed in 15 of 22 cases (68.4%) with complications, especially with severe infections such as sepsis.