小兒腎變質症之腎上腺皮質類固醇治療及長期追踪

A Long-term Study of Steroid Therapy in Children's Nephrotic Syndrome

陳烱暉(Chiung-Hui Chen)

《Acta Paediatrica Sinica》 7卷4期 (1966/12) Pp. 199-206

摘要

腎變質症之腎上腺皮質類固醇（簡稱皮質素）治療，能誘發利尿作用是周知之事實。雖關於腎上腺皮質素治療是否能延長腎變質症病孩生命之問題，是時期尚早未肯作結論，Riley等於1955年，認爲有其可能。最近Cornfeld等亦就163病例，做5年以上之長期治療觀察，而發現其死亡率僅爲15%，比腎上腺皮質素出現以前之死亡率大約40%爲低。本報告係簡述最近13年間在臺大醫院小兒科受腎上腺皮質素治療的小兒腎變質症162例經半年以上之觀察結果。

並列摘要

During the past 13 years, from 1954 to 1966, a total of 162 cases of nephrotic children were treated with corticosteroids at the Pediatric Department of National Taiwan University Hospital. During the initial treatment with steroids 23 cases or 14.2% died and proteinuria disappeared in 58.0% and continued in 27.8%. Proteinuria disappeared in two weeks after the initiation of steroid therapy in 43.6%. One case became proteinuria free after three years of treatment. A long term follow-up revealed that the mortality was 8.3%at the first year, and 34.5% at the fifth year and 58.3% at the tenth year. The presence of gross hematuria or of normocholesteremia did tot appear to affect the response of the patients to steroid therapy.