曾經注射麻疹疫苗的麻疹

Measles in Previously Vaccinated Children

鄭國彰(K. C. Cheng) ； 林守田(S. T. Lin) ； 李標柏(P. P. Lee)

《Acta Paediatrica Sinica》 15卷2期 (1974/06) Pp. 73-79

摘要

最近臺北市立中興醫院小兒科收集到二十一例過去曾經接受麻疹苗接種而經過一段時期後罹患麻疹的小兒。這二十一例均是接受Schwarz Strain的麻疹病毒經高度減毒後之乾凍狀活性疫苗，而無合併注射麻疹免疫丙球蛋白。接種時的年齡一歲以下有十三例，一歲以上有八例。自接種到發病的期間平均爲一年八個月。疫苗注射的季節有十六例(80%)集中在五月至十一月平均氣溫在23℃以上的較高溫月份內。臨床症狀與經過和自然麻疹幾乎相似，無厲害的合併症。有十六例各在發病後不同的時間抽血檢查，結果IgG量大部分高於同年齡之正常平均值，而IgM量則略低。HI抗體價最低32倍，最高4096倍，平均爲1046倍，較麻疹感染者爲高。

並列摘要

Twenty-one cases of measles who had previously been inoculated with live further attenuated measles virus vaccine (Schwarz Strain) without combining immune globulin were collected. Thirteen children had been vaccinated prior to their first birthday while eight vaccinated at the age of 13 to 30 months. The average interval from the time of vaccination to occurrence of measles was 20 months. Sixteen cases were vaccinated in hot season between May and November, the average temperature duing this period in Taiwan was over 23℃. There was no difference of clinical manifestations between the immunized and unimmunized children, and yet there were no severe complications in any of the children. Quantitative immunglobulin levels of IgG among sixteen cases tested were slightly higher than the normal mean levels, and those of IgM were less than the normal. The HI titers were 1:64 to 1:4,096 with the average of 1:1,064, which were much higher than those of the unvaccinated children who contracted measles.