A Survey on the Beta-hemolytic Streptococcal Infection among School Children in Taipei

臺北學童乙型鏈球菌感染之研究

李鍾祥(Chung-Hsiang Lee) ； 呂鴻基(Hung-Chi Lue) ； 劉建榮(Jieng-Lung Liu) ； 謝榮峰(Rhon-Phong Hsieh)

《Acta Paediatrica Sinica》 17卷1期 (1976/03) Pp. 1-12

摘要

對臺北市中心一個國校506名學童做了乙型鏈球菌感染之研究，顯示百分之36.96之學童帶有鏈球菌。其感染率與性別、年齡無關，但與父母之教育程度，家庭之擁護情況，兄弟姐妹之數目有關。分離出之鏈球菌A型佔56%，G型佔24%，麗可勝(Lincocin)注射及麗歐迅黴素(Cleocin)口服有效地降低喉內鏈球菌之帶菌率，但不能改變血清中antistreptolysin O抗體價，經過一年之觀察，187例帶菌者中沒有發現演變爲風濕熱。由於學童帶菌率之高，尋找帶菌者之困難及帶菌者演變爲風濕熱之發生率不明，著者等認爲對帶菌者全面使用抗生素以預防風濕熱之措施，似乎必要，但不實際，且未必合理。

並列摘要

A survey on the beta-hemolytic streptococcal infection was carried in a Primary school located in central Taipei. Of the 506 children studied, 187 (36.96%) were harboring beta-hemolytic streptococci in their throat. The carrier rates were not affected by sex and. age but were well correlated to the educational background of their parents, crowdingness at home and sib numbers. Among the beta-hemolytic streptococci isolated, Group A and Group G were the Prominent ones, being 56.25 and 24.38% respectively. Lincocin or Cleocin given to the streptococcal carriers for 10 days were effective in reducing the carrier rate of the beta-hemolytic streptococci, but did not affect the serum atistreptolysin O (ASO) titers. None of the 187 carrier followed developed rheumatic fever during the one year study period. Recognizing such a high prevalence of beta-hemolytic streptococcal infection, difficulties at case finding, and the uncertain attack rate of rheumatic fever among untreated carriers, we feel that administration of antimicrobial agents to all carriers for 10 days aimed at primary Prevention of rheumatic fever seems wanted, but not practical, and hard to be justified.