將近十年來對於氣喘發作病理之瞭解有長足之進步;這要包括神經藥理學及生化學-尤其是beta-2受體理論之發展、免疫學以及肺部生理學等。在這種背景之推動下,臨床診斷及治療乃有新的進展。 文中詳細討論診斷上有關過敏病史之詢問法,皮膚試驗法,IgE特異抗體之測定及標的器官的挑激試驗法等,並論及有關避免法,藥物治療法及注射療法等治療方法。
Quite a few advances in the understanding of the pathogenesis of bronchial asthma have been made in the past years. They are mainly in the fields of neuropharmacology and biochemistry concerning the concepts or problems related with beta-2 adrenergic receptors, immunology and pulmonary physiology. With these advances the methods of clinical diagnosis and treatment have improved. The purpose of the present paper is to summarize some of these important advances. In the first part of this review those related with the pathogenesis of bronchial asthma are described; in the second part, the clinical implications and some methods of clinical application, such as history taking, skin tests, immunoglobulin E antibody measurement and target organ provocation tests, and also the therapy by avoidance, use of pharmacologic agents and injection therapy are discussed.