從出生到十二個月之健康嬰兒血清免疫球蛋白G、A及M之研究(Ⅱ)母乳餵食或牛乳餵食對血清免疫球蛋白之影響

Studies on the Serum Immunoglobulin G, A and M in Healthy Infants from Birth to 12 Months of Age (Ⅱ) Effects of Types of Feeding on the Development of Serum Immunoglobulins

黃碧蓮(Bih-Liang Huang) ； 劉文章(Wen-Jang Liu) ； 呂志忠(Chu-Chong Lu) ； 陳添享(Tien-Siang Chen)

《Acta Paediatrica Sinica》 22卷1期 (1981/03) Pp. 41-48

摘要

本研究以729名出生至十二個月之健康嬰兒為對象，檢查其血清中免疫球蛋白G、A及M和濃度。729名嬰兒依餵食方式分為母乳羣、牛乳羣及混合乳羣等三羣；各羣又依年齡由出生到十二個月分爲8個年齡組，將三羣同年齡間的IgG、IgA及IgM值加以比較，結果如下：
⑴IgG值在三羣中均在出生時最高，以後很快下降，到第三個月時遠最低值，而後又逐漸上升，到十二月時約爲成人值的53%～57%。三羣同年齡組間加以比較，除九個月組母乳羣之IgG大於混合乳羣者，其餘無統計學上有意義之差異。
⑵IgM值在三羣中均自出生以後逐漸增加，到十二個月約爲成人值的57%～59%。三羣同年齡組間加以比較，無統計學上有意義之差異。
⑶IgA值在三羣中亦均自出生以後緩慢增加，到十二個月時約爲成人值的19%。其中母乳羣嬰兒在前四個月，IgA值的增加較牛乳羣及混合乳羣爲慢，尤其是在第一個月及第二個月時（分別爲8.5mg%、14.6mg%）與牛乳羣(14.4mg%、22.2mg%)及混合乳羣(14.0mg%、21.4mg)比較，呈統計學上有意義的差異。

並列摘要

In this study, serum immunoglobulin G, A and M levels in healthy infants from birth to 12 months of age were investigated. 729 serum specimens were collected from normal full term newborns in nursery and healthy infants under 12 months of age who visited out well baby clinic. These infants were divided into 3 groups-breast feeding group, bottle feeding group and mixed feeding group. Each group contained 8 subgroups by age. The concentrations of immunoglobulins were determined by the method of single radial immunodiffusion, using Behring M-partigen immunoplates. The Student's t-test was used for statistical analyses.
The results showed: (1) In all 3 groups, the concentration of Serum IgG was highest at birth, and decreased rapidly to the lowest level (breast feeding group: 467.5 mg% bottle feeding group: 514.3 mg%, mixed feeding group: 481.7 mg%) at 3 months of age, and then increased to 753.5 mg%, 730.3 mg% and 710.2 mg%, respectively, at 12 months of age. There was no significant difference in the concentrations of serum IgG among these 3 groups except at 9 months of age when the IgG of the breast-fed infants was higher than that of mixed-fed infants (P＜0.05). (2) The concentrations of serum IgM in these 3 groups increased gradually after birth and reached to 91.5 mg%, 94.7 mg% and 92.3 mg%, respectively, at the age of 12 months. There was no significant difference in the concentrations of serum IgM among these 3 groups. (3) The concentrations of serum IgA were found to rise throughout the period of infancy in these 3 groups, and reached to 49.9 mg%, 49.6 mg% and 50.1 mg%, respentively, at 12 months of age. But the speed of increase in IgA during the first months of life was slower in the breast feeding group than those in the bottle feeding group or mixed feeding group. The concentrations of IgA of breast feeding group at the age of 1 and 2 months (i. e, 8.5 mg% and 14.6 mg%) were significantly lower than those of bottle feeding group (14.4 mg% and 22.2 mg%) (P＜0.005, P＜0.025) and mixed feeding group (14.0 mg% and 21.4 mg%) (P＜0.025, P＜0.025). Such difference disappeared after 2 months of age.

並列關鍵字

immunoglobulin ； breast feeding ； bottle feeding ； Mixed feeding