小兒急性淋巴性白血病染色體之研究

Cytogenetic Studies on Acute Lymphoblastic Leukemia in Children

趙美琴(Mei-Chyn Chao) ； 陳添享(Tien-Siang Chen) ； 江季勛(Chi-Hsiun Chiang)

《Acta Paediatrica Sinica》 23卷1期 (1982/03) Pp. 36-44

摘要

高雄醫學院附設中和紀念醫院小兒科，自1979年3月至1981年10月之間，由骨髓穿刺檢查被診斷爲急性淋巴性白血病之病患有25例，包括男性15例，女性10例，年齡由9個月到14歲。利用其診斷時的白血病骨髓細胞，經過12到24小時的培養及收穫以做染色體分析。除2例外，所有的病例都在尚未接受化學抗癌劑或放射線療法之前做染色體的檢查，如果病人再發時也做同樣的檢查。25例中，11例呈染色體異常，佔44%，包括染色體的數目或構造異常。其中屬高倍體有5例，假雙倍體有5例，低倍體只有1例。染色體構造異常中，6q-有3例（1例合併高倍體47，XX，6q-，-12，+2 mar.），4q-有1例，Ph^1(22q-)1例。再發病例接受檢查者有8例，其中5例在首次與再發時染色體皆正常，1例首次正常再發時轉變爲47，XX，+12。餘2例首次異常，再發時亦出現新的異常。所有的染色體除了第1，2，3，7，8，10，13-16，X及Y染色體外，都有或多或少數目的增減，或構造的異常。由活存期觀察，染色體正常預後較佳。

並列摘要

Chromosomal studies on the bone marrow cells from twenty-five cases of childhood acute lymphocytic leukemia (ages between 9 months and 14 years, 15 males and 10 females) observed in the Pediatric Department of Kaohsiung Medical College Hospital, from March 1979 through October 1981 were performed. All cases were studied before treatment except two cases had received chemotherapy previously. The results were as follows:
1. The chromosomal abnormalities were observed in 11 out of 25 cases (about 44%). These 11 cases included 5 cases of hyperdiploid, 5pseudodiploid, and only 1hypodiploid.
2. The structural abnormalities were observed in five cases including three cases of 6q- (one of these cases was combined with 47, XX, 6q-, -12, +2 mar.), one case of 4q-, one case of Ph^1(22q-) chromosome.
3. Three of the 8 relapse cases showed karyotypic evolution.
4. All chromosomes except 1, 2, 3, 7, 8, 10, 13-16, X and Y participated in numerical and/or structural karyotypic changes.
5. The median survival of patients with initially normal karyotypes may be longer than those whose karyotypes are abnormal initially.

並列關鍵字

acute lymphocytic leukemia ； chromosomal abnormality