比較新舊Beta-Lactam類抗生素與氨基苷醣類抗生素對常見臨床分離菌之抗菌力第二報：綠膿桿菌

Antibacterial Activity of Old and New Beta-Lactam Antibiotics and Aminoglycosides against Common Clinical Isolates　Part Ⅱ. Pseudomonas Aeruginosa

朱夢麟(Mong-Ling Chu) ； 葉淑貞(Shu-Jen Yeh) ； 林明仙(Ming-Hsien Lin)

《Acta Paediatrica Sinica》 26卷1期 (1985/02) Pp. 45-53

摘要

目前綠膿得菌(Pseudomonasa aeruginosa)在各醫院中所造成的或感染是相當廣汎而嚴重的。由於此種細菌往往對於一般抗生素俱有極大的抗藥性，臨床上選擇有效之抗生素必須依據實驗室內藥物敏感性結果，故每一個地區抗生素對綠膿桿菌之感受性調查是必須而又重要的。
我們以瓊脂平板稀釋法測定102株從臨床檢體所分雜出之綠膿桿菌對於6種氨苷醣類抗生素(kanamycin, gentamicin, tobramycin, sisomicin, amikacin, netilmicin); 5種 penicillin類抗生素(penicillin, oxacillin, ampicillin, carbenicillin, piperacillin)及9種cephem類抗生素(cephalothin, cefexitin, cefmetazole, cefamandole, cefotaxime, cefmenoxime, moxalactam, cefoperazone, cefsulodin)之感受性及最小抑菌濃度。其結果顯示：在氨基苷類醣抗生素中，以amikacin為最有效。piperacillin較carbenicillin有更強抗綠膿捍菌效果，在cephem類抗生素中，第1, 2代均無效，第3代中以cefsulodin與cefoperazone之抗綠膿桿茵效果最佳。

並列摘要

In vitro antibacterial activities of 5 parenteral penicillin antibiotics (penicillin, oxacillin, ampicillin, carbenicillin and piperacillin), 9 cephem antibiotics (cephalothin, cefamandole, cefoxitin, cefmetazole, cefotaxime, moxalactam, cefoperazone, cefsulodin and cefmenoxime) and 6 aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, sisomicin, amikacin and netilmicin) were determined against 102 clinical isolates of Pseudomonas aeruginosa by the agar dilution method. Amikacin was the most active agent among. aminoglycosides. The piperacillin was more active than carbenicillin. Among the cephem antibiotics, cefsulodin and cefoperazone were the most active agents against Pseudomonas aeruginosa.

並列關鍵字

antibacterial activity ； beta-lactam antibiotics ； aminoglycosides ； Pseudomonas aeruginosa