中國學童導致尿結石之尿液生化學危險因子的分析與探討

Urinary Biochemical Risk Factors of Forming Stones in Chinese School Children

陳遠浩(Yuan-Hao Chen) ； 張錦標(Jin-Biou Chang) ； 高龐欉(Prang-Tsorng Kao) ； 馬正平(Cheng-Ping Ma) ； 黃萬出(Wann-Chu Huang) ； 陳烱暉(Chiung-Hui Chen)

《Acta Paediatrica Sinica》 27卷2期 (1986/04) Pp. 118-127

摘要

Renal calculi are much less in children than in adults, and high urinary concentrations of calcium, uric acid, urine pH and a low volume of urine are known to be risk factors. To better understand the urinary risk factors of forming stones in school children, a quantitative study of urinary biochemical constituents was performed. Except for a concentration of calcium in spot morning urine, the calcium concentrations of 8-hour urines and 24-hour urines were much higher in the age group 16 to 18 years than in other age groups (P＜0.001), the urinary concentrations of uric acid, sodium, osmolarlity and urine pH in age group of 16 to 18 years were also significantly higher than those of other age groups (P＜0.05). The results shown are quite compatible with increasing renal stone formation beginning at age 17, as analyzed on 9,936 stone formers treated at the National Taiwan University Hospital in the past 30 years. This study seems to indicate that the ages of 16 to 18 years may be the physiological risk period for urinary stone formation. As to the role of concentrations of urinary inhibitors (citrate, mucopolysaccharide, pyrophosphate etc) in school children, especially in the age group of 16 to 18 years, further investigation is needed.

並列摘要

Renal calculi are much less in children than in adults, and high urinary concentrations of calcium, uric acid, urine pH and a low volume of urine are known to be risk factors. To better understand the urinary risk factors of forming stones in school children, a quantitative study of urinary biochemical constituents was performed. Except for a concentration of calcium in spot morning urine, the calcium concentrations of 8-hour urines and 24-hour urines were much higher in the age group 16 to 18 years than in other age groups (P＜0.001), the urinary concentrations of uric acid, sodium, osmolarlity and urine pH in age group of 16 to 18 years were also significantly higher than those of other age groups (P＜0.05). The results shown are quite compatible with increasing renal stone formation beginning at age 17, as analyzed on 9,936 stone formers treated at the National Taiwan University Hospital in the past 30 years. This study seems to indicate that the ages of 16 to 18 years may be the physiological risk period for urinary stone formation. As to the role of concentrations of urinary inhibitors (citrate, mucopolysaccharide, pyrophosphate etc) in school children, especially in the age group of 16 to 18 years, further investigation is needed.

並列關鍵字

renal stone ； urinary electrolyte concentration ； urinary uric acid concentration