新生兒血清前白蛋白濃度的臨床意義

Clinical Implication of Serum Prealbuinin Concentration in Newborn

葉欽池(Chin-Chie Yeh) ； 陳武元(Wu-Yuen Chen) ； 劉文章(Wen-Jang Liu) ； 呂志忠(Chu-Chong Lu) ； 江季勛(Chi-Hsiun Chiang) ； 黃德揚(Teh-Yang Huang) ； 陳添享(Tien-Siang Chen)

《Acta Paediatrica Sinica》 27卷2期 (1986/04) Pp. 99-105

摘要

The purpose of this study is to detect the changes of serum prealbumin concentration in newborn infants. Seventy four normal newborns were checked daily after birth; twenty premature infants were checked weekly, and sixty-two sick infants were checked frequently. The results revealed that the serum prealbumin concentration in normal newborns was 12.10±2.28mg/dl on the first day, with a decline in the next two days to the lowest level of 8.36±1.58mg/dl, then a gradual rise to 14.07±3.42mg/dl on the seventh day.
The serum prealbumin concentrations increased in correlation with the increment of gestational age in both full term and premature newborns on the first day after birth. In infants with sepsis or severe neonatal infection, the serum prealbumin level was low (8.7±1.78mg/dl), and it was significantly lower than that of infants with mild upper respiratory tract infection (P＜0.01).
In newborns with neonatal hepatitis and biliary atresia, the serum prealbumin decreased if the liver function was impaired, with a gradual increase to normal level after treatment. However, it remained low in cases without effective treatment. In four infants with diarrhea for more than six days, the serum prealbumin levels were low. In cases of idiopathic neonatal hyperbilirubinemia, the serum prealbumin concentration was normal (15.00±3.90mg/dl).

並列摘要

The purpose of this study is to detect the changes of serum prealbumin concentration in newborn infants. Seventy four normal newborns were checked daily after birth; twenty premature infants were checked weekly, and sixty-two sick infants were checked frequently. The results revealed that the serum prealbumin concentration in normal newborns was 12.10±2.28mg/dl on the first day, with a decline in the next two days to the lowest level of 8.36±1.58mg/dl, then a gradual rise to 14.07±3.42mg/dl on the seventh day.
The serum prealbumin concentrations increased in correlation with the increment of gestational age in both full term and premature newborns on the first day after birth. In infants with sepsis or severe neonatal infection, the serum prealbumin level was low (8.7±1.78mg/dl), and it was significantly lower than that of infants with mild upper respiratory tract infection (P＜0.01).
In newborns with neonatal hepatitis and biliary atresia, the serum prealbumin decreased if the liver function was impaired, with a gradual increase to normal level after treatment. However, it remained low in cases without effective treatment. In four infants with diarrhea for more than six days, the serum prealbumin levels were low. In cases of idiopathic neonatal hyperbilirubinemia, the serum prealbumin concentration was normal (15.00±3.90mg/dl).

並列關鍵字

prealbumin ； retinol-binding protein ； thyroxine