Effects of Oral Clonidine on the Secretion of Serum Growth Hormone in Children and Adolescents in Short Stature

口服Clonidine對身材矮小兒童生長激素分泌之影響

蔡文友(Wen-Yu Tsai) ； 陳森輝(Shen-Hui Chen)

《Acta Paediatrica Sinica》 28卷4期 (1987/08) Pp. 205-211

摘要

28位身材矮小兒童以口服Cloniding可(0.15mg/m^2)刺激其生長激素之分泌，並以之與靜脈注射胰島素所得的結果相比較。雖然在無生長激素缺乏之孩童，Clonidine所引發的血清生長激素反應的最大值未必比胰島素所引發者高，可是Clonidine引發低於正常反應的機會比胰島素少。基於此發現，加上服用 Clonidine並未發生令人無法接受之副作用，我們認為欲測定孩童生長激素之分泌功能，口服Clonidine不失為一簡單、安全而且值得信賴之試驗。

並列摘要

The efficiency of oral clonidine (0.15mg/m^2 body surface area) as a stimulant for growth hormone release was evaluated in 28 children and adolescents with short stature. Serum growth hormone response to oral clonidine was compared with that to intravenous insulin. Although clonidine did not consistently provoke a higher serum growth hormone response in those without growth hormone deficiency, it gave fewer false subnormal responses than insulin. In view of these findings and The absence of unacceptable side effects with clonidine, it is concluded that the oral administration of clonidine is a simple, safe and reliable test for growth hormone secretion.

並列關鍵字

growth hormone ； short stature ； insulin hypoglycemic test ； clonidine tolerance test