過敏性氣喘及系統性狼瘡性紅斑病兒血清型干擾素及其抗體之研究

Serum α-Interferon and α-Interferon Antibody in Children with Allergic bronchial Asthma and Systemic Lupus Erythematosus

劉文章(Wen-Jang Liu) ； 呂志忠(Chu-Chong Lu) ； 江季勛(Chi-Hsiun Chiang) ； 黃德揚(Teh-Yang Huang) ； 劉宏文(Hong-Wen Liu)

《Acta Paediatrica Sinica》 29卷3期 (1988/06) Pp. 159-166

摘要

The purpose of this study was to determine the a-interferon (α-TFN) and α-interferon antibodies (α-IFN Ab) in allergic bronchial asthma and systemic lupus erythematosus (SLE) and their correlation to the disease activity. Sera from 22 healthy and 15 respiratory tract infection children were used as controls, twenty sera from inactive stage SLE, fifty-three sera from thirty-one newly diagnosed and twenty-two well treated asthmatic patients were studied. The α-IFN was determined with RIA (Sucrospe; Boots-Celltech Diagnostics Ltd, UK) and α-TFN Ab with EIA (ANAWA Laboratorien AG Switzerland). Serum α-IFN was detected in 53.3% (8/15) of respiratory tract infection, 40.0% (8/20) of SLE, 32.3% (10/31) of newly diagnosed and 22.7% (5/22) of well treated asthmatics. By contrast, it was undetectable in all healthy children. Serumα-IFN Ab was detected in 9.6% (3/31) of newly diagnosesd asthmatics only. The possible role of α-IFN and α-IFN Ab in the pathogenesis of allergic bronchial asthma and SLE has been discussed.

並列摘要

The purpose of this study was to determine the a-interferon (α-TFN) and α-interferon antibodies (α-IFN Ab) in allergic bronchial asthma and systemic lupus erythematosus (SLE) and their correlation to the disease activity. Sera from 22 healthy and 15 respiratory tract infection children were used as controls, twenty sera from inactive stage SLE, fifty-three sera from thirty-one newly diagnosed and twenty-two well treated asthmatic patients were studied. The α-IFN was determined with RIA (Sucrospe; Boots-Celltech Diagnostics Ltd, UK) and α-TFN Ab with EIA (ANAWA Laboratorien AG Switzerland). Serum α-IFN was detected in 53.3% (8/15) of respiratory tract infection, 40.0% (8/20) of SLE, 32.3% (10/31) of newly diagnosed and 22.7% (5/22) of well treated asthmatics. By contrast, it was undetectable in all healthy children. Serumα-IFN Ab was detected in 9.6% (3/31) of newly diagnosesd asthmatics only. The possible role of α-IFN and α-IFN Ab in the pathogenesis of allergic bronchial asthma and SLE has been discussed.

並列關鍵字

α-interferon ； α-interferon antibody ； allergic bronchial asthma ； systemic lupus erythematosus