Reevaluation of Streptococcal Infection in the Pathogenesis of Kawasaki Disease

鏈球菌感染對川崎病病因之再評估

沈慶村(Ching-Tsuen Shen) ； 王南焜(Hsieh-Yin Wu) ； 吳雪穎(Nan-Koong Wang) ； 黃慶三(Ching-Shan Huang)

《Acta Paediatrica Sinica》 31卷3期 (1990/06) Pp. 144-150

摘要

鏈球菌一再被懷疑爲引起川崎病之病因，而鏈球菌本身之産物如紅皮毒素(ERYTHROTOXIN)，鏈溶素(STREP-TOLYSIN),M蛋白，C抗原及PEPTI-DOGLYCANS等也對心臓血管內皮具侵害作用。本篇乃於1977至1987年間罹患川崎病幼兒49人中（年齡4個月到15歲。平均2.2歲）及罹患上呼吸道感染無其他併發症幼兒191人中（年齡自2個月到15歲平均6.4歲）。其急性期的喉頭拭子細菌培養及恢復期之鏈溶素抗體濃厚加以收集分析。結果發現川崎病患兒之喉頭拭子細菌培養不但沒有較高的鏈球菌陽性率，而恢復期的鏈溶素抗體不管在0-1、l-3、3-6、6-15歲組羣都沒有比一般上呼吸道感染的患兒高，因此認爲川崎病的發生與咽喉鏈球菌感染無直接關連。

並列摘要

Twenty-five sera from forty-nine children with Kawasaki disease (KD) in the convalescent stage, and 191 sera from controls did not disclose a higher anti-streptolysin O titer; 23 bacterial cultures from the throat swab of KD patients during the acute stage did not show a higher rate of streptococcal isolation. It was therefore concluded that there was no relation between the genesis of KD and direct immediate streptococcal infection.

並列關鍵字

Kawasaki disease ； streptococcal infection