Cytomegalovirus-Associated Neonatal Hepatitis

與巨細病毒有關之新生兒肝炎

賴明瑋(Ming-Wei Lai) ； 張美惠(Mei-Hwei Chang) ； 李慶雲(Chin-Yun Lee) ； 許輝吉(Hey-Chi Hsu) ； 高全良(Chuan-Liang Kau)

《Acta Paediatrica Sinica》 33卷4期 (1992/08) Pp. 264-272

摘要

Fifty-five with cytomegalovirus (CMV) -associated neonatal hepatitis (NH) were followed for 12 to 90 months. Six patients (10.9%) died from either a fulminant course or a chronic liver disease. Among the remaining 49 patients, whose liver function was completely recovered, there were eight with retardation of developmental or growth status, and two with hearing impairment. Overall, 20.4% of the survivors suffered from a long-term impact. The unfavorable outcome was related to several clinical and pathological parameters. These included persistence of clay-colored stool, presence of splenomegaly, ascites or anemia, high peak total and direct bilirubin, low nadir albumin levels, diffuse giant cell transformation and cirrhosis of the liver. The seropositivity of CMV infection did not significantly correlate with the outcome.

並列摘要

Fifty-five with cytomegalovirus (CMV) -associated neonatal hepatitis (NH) were followed for 12 to 90 months. Six patients (10.9%) died from either a fulminant course or a chronic liver disease. Among the remaining 49 patients, whose liver function was completely recovered, there were eight with retardation of developmental or growth status, and two with hearing impairment. Overall, 20.4% of the survivors suffered from a long-term impact. The unfavorable outcome was related to several clinical and pathological parameters. These included persistence of clay-colored stool, presence of splenomegaly, ascites or anemia, high peak total and direct bilirubin, low nadir albumin levels, diffuse giant cell transformation and cirrhosis of the liver. The seropositivity of CMV infection did not significantly correlate with the outcome.

並列關鍵字

neonatal hepatitis ； cytomegalovirus infection