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Risk Factors of Coronary Arterial Aneurysm in Kawasaki Disease

川崎病冠狀動脈瘤之危險因子

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摘要


冠狀動脈瘤是川崎病最常見且嚴重之併發症,雙向超音波可用來檢查此症患者的冠狀動脈。民國72年4月至81年8月本院共有70例(男47,女23)診斷為川崎病的病童,其中57例病童在急性期僅接受阿斯匹林80-100毫克/公斤/天之治療,並且接受超音波追蹤檢查兩個月至兩年之久。十二例(21%)發現有冠狀動脈瘤形成,稱為高危險群,其餘四十五例則稱為低危險群。我們先以單變數統計方法來檢驗十六個臨床和實驗變數,發現在兩群中只有白血球和C-反應蛋白質具有統計上之顯著差異。進一步使用逐步區別分析後,發現此二變數結合所形成之區別函數可用來預測、區別病患歸屬於高危險群或低危險群。正確區別率為75%。

關鍵字

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並列摘要


From April 1983 to August 1991, 70 cases of Kawasaki disease were admitted to Taiwan Provincial Tao-Yuan General Hospital Fifty-seven patients treated with aspirin 80-100 mg/kg/day alone during the acute phase were followed by two-dimensional echocardiography for two weeks to two years. Twelve cases (21%) complicated with coronary arterial aneurysm (CAA) were referred as high risk group. Those who had no CAA were a low risk group. Stepwise discriminant analysis was performed to obtain risk factors of CAA based on clinical and early laboratory data. This yielded a classification accuracy of 75.4%. The combination of two parameters, white blood cell count and C-reactive protein, can be applied to early identify Kawasaki patients at high or low risk of CAA.

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