Epstein-Barr Virus Pneumonia Associated with Hemophagocytic Syndrome: Report of One Case

EB病毒肺炎合併血球吞噬症候群：一病例報告

高志嘉(Chih-Chia Kao) ； 黃富源(Fu-Yuan Huang) ； 梁德城(Der-Cherng Liang)

《Acta Paediatrica Sinica》 35卷4期 (1994/08) Pp. 325-330

https://doi.org/10.7097/APS.199408.0325

摘要

本文報告一位八歲大之女孩，因發燒和咳嗽七天而於本院住院，理學檢查發現左肺有彌漫性的濕曪音。然後漸漸發現有持續性高燒，肝脾腫大，淋巴腺腫大，皮膚疹子，結膜下出血，彌漫性肺部浸潤，不正常的肝功能檢查，貧血，血小板減少，白血球過多，和低白蛋白血症，骨髓檢查顯示具有明顯血球吞噬的巨吞噬細胞數目增加。後來産生呼吸衰竭而需要人工呼吸器幫助呼吸，最後，病人死於呼吸衰竭。剛開始EB病毒的血清學檢查無異常發現，但是，於住院後第二十四天，EB病毒的血清學檢查發現：anti-VCA IgG 320x(+),anti-VCA IgG(+)。這是一個非常罕見的致命性EB病毒肺炎合併血球吞噬症候群的病例。

關鍵字

EB病毒 ； 肺炎 ； 血球吞噬症候群

並列摘要

An 8-year-old girl was admitted because of high fever and cough for seven days. The physical examination on admission revealed diffuse moist rales over the left lung field. Her high fever persisted, and she subsequently developed hepatosplenomegaly, lymphadenopathy, skin rashes, subconjunctival hemorrhage, diffuse pulmonary infiltrates, abnormal liver function, anemia, thrombocytopenia, leukocytosis, and hypoalbuminemia. A bone marrow study revealed increased numbers of macrophages with apparent hemophagocytosis. She developed respiratory failure and required artificial ventilation, but finally died despite resuscitative efforts. Serology for EB virus initially revealed negative findings, but on the 24th day after admission, showed IgG antibody to viral capsid antigen 320χ (+), and IgM antibody to viral capsid antigen (+). This is a very unusual case of fatal EB virus pneumonia associated with hemophagocytic syndrome.

並列關鍵字

EB virus ； pneumonia ； hemophagocytic syndrome