The Effects of Anticonvulsants on the Epileptiform Discharges-Study by 24-hour Ambulatory Cassette EEG System

抗癲癇藥物對癲癇波之影響－以攜帶式24掌上電腦腦波儀量化研究－

劉文玉(Wen-Yu Liou) ； 曹汶龍(Wen-Long Tsao) ； 張民基(Ming-Key Chang) ； 朱夢麟(Mong-Ling Chu)

《Acta Paediatrica Sinica》 35卷6期 (1994/12) Pp. 522-529

https://doi.org/10.7097/APS.199412.0522

摘要

11位腦波具泛發性及11位具局部性癲癇波且未曾使用癲癇藥治療之兒童癲癇病人，以Oxford Medilog 9200型24小時攜帶式腦波儀進行本研究。電極依國際1020系統依次爲下齶肌電圖，眼震圖，FP1-T3，T3-C3，C3-O1，FP2-T4，T4-C4，C4-O2。病人進行用藥前後24小時腦波檢查後比較其癲癇波數之變化。11位具泛發性癲癇波者隊1例慢銳慢波，1例不規則棘慢波其波數未減少外，9例之癲癇波均隨用藥而完全消失。另外11位具局部癲癇波者，3例中間溝顳葉棘波波數未減少，另2例中間溝－顳葉棘波及4例顳葉棘波之波數呈明顯減少，2例枕葉棘波則因用藥而完全消失。

關鍵字

癲癇 ； 抗癲癇藥 ； 攜帶式24小時腦波圖

並列摘要

Thirty-three epileptic children who had epileptiform discharges in conventional 16 channel EEG study were enrolled in this study. The patients have never been treated with medication at first visit. Then patient were put on ambulatory monitoring EEG with the Oxford Medilog 9-channel cassette LEG system, which included six symmetrical scalp leads, one EOG, one Chin EMG and one channel for time signal. The LEG record was processed under the rule of the international standard method in terms of 10-20 system. The 24 hours EEG cassettes which recorded before and after antiepileptic drugs therapy were reviewed by an experienced electroencephalographer on a video play back unit. The number and duration of spikes or spike wave discharges were calculated. Among those 22 cases who had studied completed, there are 11 cases with generalized spike waves (5 with irregular spike waves, 3 with regular 3 hz spike waves, 1 with multiple spike waves, 1 with slow sharp waves and 1 with abortive spike waves), and 11 cases with focal spike activities (5 with bilateral central or centrotemporal spikes, 4 with temporal spikes and 2 with occipital spike discharges). After anticonvulsants therapy, 9 cases (82%) out of those 11 cases with generalized spike waves, the spike waves were disappeared; 2 cases (18%) revealed no significant change in spike rate and duration. In another 11 cases with focal spike discharges, 3 cases with centrotemporal spikes showed no significant change in spike rate, 2 cases with centrotemporal spikes and 4 cases with temporal spikes revealed significant decrease in spike rate; The occipital paroxysms of the last two cases were totally disappeared after medication. We found that most of generalized spike waves and occipital spike activities could be abolished totally by anticonvulsants, temporal spike discharges revealed marked decrease in spike rate after therapy, whereas, most of central or centrotemporal spike discharges showed no significant change in spike rate after antiepileptic drugs therapy.

並列關鍵字

epilepsy ； anticonvulsants ； ambulatory 24-hour electroencephalogram