Relationship Between Hemodynamics and Plasma Atrial Natriuretic Peptide in Children with Ventricular Septal Defect or Patent Ductus Arteriosus

心室中隔缺損或開放性動脈導管之病兒其血行動力學與心房利鈉勝肽之相關性

戴任恭(Zen-Rong Dai) ； 黃德揚(The-Yang Huang) ； 吳俊仁(Jun-Ren Wu) ； 黃旼儀(Ming-Yii Huang)

《Acta Paediatrica Sinica》 36卷2期 (1995/04) Pp. 86-92

https://doi.org/10.7097/APS.199504.0086

摘要

To evaluate the relationship between concentrations of ANP in plasma of the right-sided central circulation and hemodynamic parameters in congenital heart disease with left-to-right shunt, We enrolled 20 children aged from 1 month to 4.8 years with ventricular septal defect (VSD) or patent ductus arteriosus (FDA). The concentrations of ANP in plasma were extracted through a cartridge (Sep-Pak C,8) before being measured by radioimmunoassay. Significant increased concentrations of ANP in plasma from inferior vena cava (117.6±18.1pg/mL), right atrium (160.6±21.6pg/mL) to pulmonary artery (PA) (253.4±38.8pg/mL) were recognized. In VSD (n=10) and FDA (n=10), the concentrations of ANP in plasma from the inferior vena cava correlated significantly with the ratio of pulmonary to systemic blood flow (Qp/Qs) (r=0.69, p＜0.05; r=0.94, p＜0.0l respectively), the systolic pulmonary artery pressure (r=0.90, p＜0.01; r=0.93, p＜0.01 respectively), the diastolic pulmonary artery pressure (r=0.76, p＜0.02, r=0.68, p＜0.05 respectively), and the mean pulmonary artery pressure (r=0.88, p＜0.0l; r=0.87, p＜0.0l respectively). The concentrations of ANP in plasma from the pulmonary artery also correlated significantly with the Qp/Qs (r＜0.81, p＜0.0l; r=0.87, p＜0.0l respectively). The results indicated that left atrial volume loading may have an important influence on secretion of ANP in some congenital heart disease with left to right shunt.

關鍵字

心房利鈉勝肽 ； 心室中隔缺損 ； 開放性動脈導管

並列摘要

To evaluate the relationship between concentrations of ANP in plasma of the right-sided central circulation and hemodynamic parameters in congenital heart disease with left-to-right shunt, We enrolled 20 children aged from 1 month to 4.8 years with ventricular septal defect (VSD) or patent ductus arteriosus (FDA). The concentrations of ANP in plasma were extracted through a cartridge (Sep-Pak C,8) before being measured by radioimmunoassay. Significant increased concentrations of ANP in plasma from inferior vena cava (117.6±18.1pg/mL), right atrium (160.6±21.6pg/mL) to pulmonary artery (PA) (253.4±38.8pg/mL) were recognized. In VSD (n=10) and FDA (n=10), the concentrations of ANP in plasma from the inferior vena cava correlated significantly with the ratio of pulmonary to systemic blood flow (Qp/Qs) (r=0.69, p＜0.05; r=0.94, p＜0.0l respectively), the systolic pulmonary artery pressure (r=0.90, p＜0.01; r=0.93, p＜0.01 respectively), the diastolic pulmonary artery pressure (r=0.76, p＜0.02, r=0.68, p＜0.05 respectively), and the mean pulmonary artery pressure (r=0.88, p＜0.0l; r=0.87, p＜0.0l respectively). The concentrations of ANP in plasma from the pulmonary artery also correlated significantly with the Qp/Qs (r＜0.81, p＜0.0l; r=0.87, p＜0.0l respectively). The results indicated that left atrial volume loading may have an important influence on secretion of ANP in some congenital heart disease with left to right shunt.

並列關鍵字

atrial natriuretic peptide (ANP) ； ventricular septal defect ； patent ductus arteriosus