- 期刊
Rotavirus Gastroenteritis Associated with Afebrile Seizure in Childhood
兒童期輪狀病毒腸胃炎合併非熱性痙攣
摘要
自1994年9月至1995年4月，我們蒐集到8個年齡介於1歲半至9歲的病童，其主訴爲急性腹瀉之後合併有發生痙攣或神智不清兼有尿失禁。這些病童皆無發燒現象且血中電解質均在正常範圍之內，血液細菌培養均呈陰性反應；而腹瀉原因皆爲輪狀病毒感染；腦脊髓液檢查包括血球數目、蛋白質、糖份皆在正常範圍內，腦脊髓液之細菌及病毒培養均呈陰性反應。 在痙攣發生之後1至13天內對這8個病童施行腦波檢查，其中有6個病童爲不正常、2個病童爲正常。在痙攣發生4到11個月之後，再對所有病童所做的腦波檢查均正常，在追蹤期間無任何病童接受長期抗痙攣藥物治療且均無人再有痙攣發生。 根據作者的觀察，輪狀病毒與輪狀病毒腸胃炎合併之非熱性痙攣有密切的關係，而此類痙攣通常預後良好，至於其病理機轉仍需進一步的研究。
並列摘要
From September 1994 to April 1995, we encountered eight children, two boys and six girls, (aged 1 year 6 months to 9 years), presented with acute diarrhea followed by afebrile, generalized tonic-clonic seizures, or transient loss of consciousness with urine incontinence. Their biochemical data, including serum electrolyte levels, were within normal limits. The infective agent causing diarrhea was later proved by stool examination to be rotavirus, judged to be serotype GI by reverse transcription-polymerase chain reaction (RT-PCR) typing. Cerebrospinal fluid (CSF) examinations performed in seven of the eight patients were within normal limits, and cultures for bacteria and virus were negative. The electroencephalograms (EEGs) performed from 1 to 13 days after seizure showed abnormal in six, and normal in two, patients. Follow-up EEGs, performed from 4 to 11 months after onset of seizure, were all normal. None had seizure recurrence despite the fact that no long-term anticonvulsant had been given. From observation here, the authors emphasize that there is a close relationship between rotavirus and afebrile seizure, and the course of afebrile seizure following rotaviraus gastroenteritis is usually benign. Further studies are needed to elucidate the underlying pathogenesis.