Effect of Continuous Positive Airway Pressure on Cardiac Output in Neonates

持續性正壓呼吸對新生兒心輸出量的影響

徐惠松(Huei-Song Hsu) ； 陳偉德(Walter Chen) ； 王南焜(Nan-Koong Wang)

《Acta Paediatrica Sinica》 37卷5期 (1996/10) Pp. 353-356

https://doi.org/10.7097/APS.199610.0353

摘要

爲判定新生兒使用經鼻式持續性正壓呼吸治療後，心輸出量的改變，在本院新生兒加護病房，共有11位初生的新生兒加入了此研究，病人皆因呼吸道疾病而需要持續性正壓呼吸來治療。我們用脈衝式杜卜勒超音波來測量心輸出量。結果顯示，壓力在0，2，4，6，8，和10公分水柱時，所沒得的心輸出量分別爲301±47，300±49，289±55，275±64，269±59和242±50毫昇／分鍾／公斤。當壓力逐步提高時，心輸出量有明顯的降低。我們的結論是新生兒使用較高壓力的經鼻式持續性正壓呼吸治療時，可能會導致心輸出量的降低；且建議當使用高壓力的持續性正壓呼吸治療時必須小心，特別是低體重的新生兒。

關鍵字

持續性正壓呼吸 ； 心輸出量 ； 杜卜勒心臓超音波

並列摘要

To determine the cardiac output change in neonates who were under nasal continuous positive airway pressure (CPAP) therapy, eleven newborn neonates, who were admitted to our neonatal intensive care unit with respiratory diseases, were enrolled in the study. Cardiac output was measured by pulsed Doppler echocardiogram at various pressures of 0, 2, 4, 6, 8, and 10cm H2O and revealed 301±47, 300±49, 289±55, 275±64, 269±59 and 242±50ml/min/kg, respectively. Cardiac output depressed significantly between 0 cm H2O and 8cm H2O (P=0.025), and between 0cm H2O and 10cm H2O (P=0.004). We conclude that cardiac output may be depressed in neonates who are under high levels of nasal CPAP therapy, and suggest that high levels of nasal CPAP therapy must be used with caution, especially when the therapy is applied to the low birth weight neonates.

並列關鍵字

continuous positive airway pressure ； cardiac output ； Doppler echocardiography