- 期刊
Impaired Immune Function in a Premature Infant with Zinc Deficiency after Total Parenteral Nutrition
全靜脈營養後合併鋅缺乏導致一早産兒之免疫功能不全
摘要
一早産兒因壞死性腸炎而接受全靜脈營養的治療，約三至四週後，開始有鋅缺乏的現象。其臨床特徵包括皮疹、毛髪脫落、生長遲緩、全身性浮腫、及血清堿性磷酸酵素(ALP)的降低。免疫功能方面的研究顯示中性球黏合功能和淋巴球絲狀分裂素受激反應受損，而其吞噬作用、趨化性及淋巴球分類則爲正常。患兒在投予高劑量口服的鋅(2.5mg/kg/day)後，其産床症狀和免疫功能獲得顯著改善。病人因鋅缺乏而有中性球黏合功能受損的現象，可能造成免疫不全症，此現象可因補充足夠的鋅而獨得顯著的緩解。
並列摘要
The report describes a premature infant with necrotizing enterocolitis who developed symptoms of zinc (Zn) deficiency after three to four weeks of total parenteral nutrition (TPN). Clinical presentations included characteristic skin rash, alopecia, retarded growth, generalized edema and decreased serum alkaline phosphatase (ALP). Immune function studies revealed impaired neutrophil adhesion and mitogen-induced lymphoproliferation, whereas phagocytosis, chemotaxis and lymphocyte subsets remained normal. A high dose of elemental Zn (2.5mg/kg/day), administered orally, improved the clinical symptoms and restored the immune function. In patients with Zn deficiency, impaired neutrophil adhesion and lymphocyte function may contribute to immunodeficiency which can be reversed with adequate Zn supplementation.