- 期刊
Bacteria-Associated Hemophagocytic Syndrome in Childhood Acute Lymphoblastic Leukemia: Report of Two Cases
兒童急性淋巴性白血病并發細菌引起之血球吞嗜症候群：二病例報告
摘要
本文敘述二位急性淋巴性白血病兒童，罹患蜂窩組織炎合併敗血症，病人於感染後併發血球吞嗜症候群，其表現有發燒不退，黃疸，全血球降低，血液凝固異常，及骨髓內組織球增多併血球吞嗜現象，此病是由細菌引起，其與病毒引起的血球吞嗜症候不同之處，在於缺少淋巴腺腫大，皮疹，及肝脾腫大，此二例皆已排除病毒感染之可能性，二例在經過抗生素及免疫球蛋白治療之後，症狀皆獲得改善，這是文獻中少數治療成功的病例，特提出報告。
並列摘要
Two children with acute lymphoblastic leukemia presenting with cellulitis and sepsis are described. Both presented as having hemophagocytic syndrome with the manifestations of prolonged fever, jaundice, pancytopenia, coagulopathy and histiocytic proliferation with hemophagocytosis in their bone marrows. It is similar to the virus-associated hemophagocytic syndrome (VAHS), except for the absences of lymphadenopathy, skin rash and hepatosplenomegaly. Concomitant virus infections were excluded in these two cases. Both patients’ conditions improved after appropriate antibiotics and intravenous immunoglobulin therapy. The prognosis seemed better in bacteria-associated hemophagocytic syndrome (BAHS) than in VAHS even in immunocompromised patients.
延伸閱讀
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