Correlation of Quantitative Renal Cortical Echogenicity with Renal Function in Pediatric Renal Diseases

小兒腎病疾病量化腎皮質超音波回音強度與腎功能之相關性

曹永魁(Yong-Kwei Tsau) ； 李秉穎(Ping-Ing Lee) ； 張鑾英(Luan-Yin Chang) ； 陳烱暉(Chiung-Hui Chen)

《Acta Paediatrica Sinica》 38卷4期 (1997/08) Pp. 276-281

https://doi.org/10.7097/APS.199708.0276

摘要

Using quantitative echogenicity, the correlation between renal cortical echogenicity and renal function (serum creatinine) was evaluated in pediatric renal diseases. The kidney/liver echogenicity ratio (K/L ratio) was measured by computerized amplitude histogram in 20 healthy children as well as in 45 children with renal diseases, including 12 glomerulonephritis with chronic renal failure (CRF), 9 anatomic- related CRF, 9 glomerulonephritis with acute renal failure (ARF), 5 nephrotoxic ARF, and 10 glomerulonephritis without renal failure. All children were above six years of age. Simultaneous serum creatinine was available during the procedure in all patients. The overall K/L ratio was 1.38 ± 0.26 for CRF and 1.14 ± 0.18 for ARF (p=0.007), while the overall serum creatinine was 312 ± 160//mol/L (3.5 ± 1.8 mg/dl) and 191 ± 73 μmol/L (2.2 ± 0.8 mg/dl), respectively (p=0.013). K/L ratio was higher in CRF at a higher, or even at a comparable serum creatinine level, than in ARF. For patients with glomerulonephritis, K/L ratio was highest in those with CRF, next in those with ARF. Even in glomerulonephritis without renal failure, the K/L ratio was higher than in normal controls. There was a positive correlation between K/L ratio and serum creatinine concentration in glomerulonephritis with or without renal failure (r=0.69, p＜0.001). These results suggest that the degree of increased renal echogenicity may reflect the severity of the renal disease. The K/L ratio measured by quantitative echogenicity may provide an additional simple noninvasive method to monitor the progression of glomerulonephritis.

關鍵字

小兒超音波 ； 超音波回音強度 ； 腎絲球腎炎 ； 腎衰謁

並列摘要

Using quantitative echogenicity, the correlation between renal cortical echogenicity and renal function (serum creatinine) was evaluated in pediatric renal diseases. The kidney/liver echogenicity ratio (K/L ratio) was measured by computerized amplitude histogram in 20 healthy children as well as in 45 children with renal diseases, including 12 glomerulonephritis with chronic renal failure (CRF), 9 anatomic- related CRF, 9 glomerulonephritis with acute renal failure (ARF), 5 nephrotoxic ARF, and 10 glomerulonephritis without renal failure. All children were above six years of age. Simultaneous serum creatinine was available during the procedure in all patients. The overall K/L ratio was 1.38 ± 0.26 for CRF and 1.14 ± 0.18 for ARF (p=0.007), while the overall serum creatinine was 312 ± 160//mol/L (3.5 ± 1.8 mg/dl) and 191 ± 73 μmol/L (2.2 ± 0.8 mg/dl), respectively (p=0.013). K/L ratio was higher in CRF at a higher, or even at a comparable serum creatinine level, than in ARF. For patients with glomerulonephritis, K/L ratio was highest in those with CRF, next in those with ARF. Even in glomerulonephritis without renal failure, the K/L ratio was higher than in normal controls. There was a positive correlation between K/L ratio and serum creatinine concentration in glomerulonephritis with or without renal failure (r=0.69, p＜0.001). These results suggest that the degree of increased renal echogenicity may reflect the severity of the renal disease. The K/L ratio measured by quantitative echogenicity may provide an additional simple noninvasive method to monitor the progression of glomerulonephritis.

並列關鍵字

pediatric ultrasound ； echogenicity ； glomerulonephritis ； renal failure