Developmental Changes in α-tocopherol, Especially during Infantile Period

α-Tocopherol 在發育期，特別於嬰兒期之變化

Hiroshi Tamai ； Han-Suk Kim ； Hiroyuki Arai ； Keizo Inoue ； Makoto Mino

《Acta Paediatrica Sinica》 38卷6期 (1997/12) Pp. 429-431

https://doi.org/10.7097/APS.199712.0429

並列摘要

Developmental changes in expression of α-TTP after birth were investigated using rats with respect to plasma changes of tocopherols. The expression of α-TTP in the neonatal rat liver, which was very low immediately after birth, increased steadily during the two weeks of life before weanling and reached the adult level at 4 weeks. During the suckling period, the plasma ratio of α-tocopherol to γ-tocopherol linearly increased, because plasma α-tocopherol was low immediately after birth, increased rapidly during the period, while γ-tocopherol remained unchanged. The increase in the ratio seemed to correlate with the developmental expression of α-TTP in the liver during this period. The ratio also reached the adult level after 4 weeks. The expression of α-TTP was investigated using primary cultured rat hepatocytes. The expression of α-TTP was found to be extremely low after 20h of culture. The decrease in α-TTP expression was exacerbated by adding epidermal growth factor to the culture medium and was inhibited by adding dexamethasone. These observations suggest that expression of α-TTP may be affected by the state of hepatic differentiation. The Western and Northern blot analysis of α-TTP in vitamin E deficient and enriched rats were compared to control rats. The decrease of mRNA of α-TTP observed in α-Toc-enriched rat liver and the increase of mRNA observed in the vitamin E deficient rat liver indicate the synthesis of α-TTP, although α-TTP itself was not altered.

並列關鍵字

α-tocopherol ； γ-tocopherol ； α-tocopherol transfer protein ； discrimination