Evaluation of a Live Attenuated Varicella Vaccine in 15- to 18-Month-Old Healthy Children

活性減毒水痘疫苗接種於15-18月大健康幼兒之評估

盧孟佑(Meng-Yao Lu) ； 黃立民(Li-Min Huang) ； 李慶雲(Chin-Yun Lee) ； 李秉穎(Ping-Ing Lee) ； 丘秀慧(Hsui-Hui Chiu) ； 蔡秀媛(Hsiu-Yuan Tsai)

《Acta Paediatrica Sinica》 39卷1期 (1998/02) Pp. 38-42

https://doi.org/10.7097/APS.199802.0038

摘要

爲評估活性減毒水痘疫苗對15-18月大健康幼兒之案例性及免疫效益，本研究對118位15至18月大的健康幼兒，同時分開接種一劑活性減毒水痘疫苗和一劑麻疹-德國麻診-腮腺炎混合疫苗於左右大腿，觀察其副作用及免疫效益。結果顯示注射反應極輕微，約2%接種者出現皮疹，但都沒有水泡出現。接種後六週測血清免疫反應，100%接種者對水痘病毒産生免疫力。與麻疹-德國痳診-腮腺炎混合疫苗同時分開接種並未減低麻疹-德國麻疹-腮腺炎混合疫苗之效益或增加接種反應性。由此研究可發現活性減毒不痘疫苗和麻疹-德國麻疹-腮腺炎混合疫苗混合同時接種是相當方便、安全且有效的措施。

關鍵字

活性減毒水痘疫苗 ； 疫苗接種 ； 痳疹 ； 德國痳疹 ； 腮腺炎

並列摘要

A clinical trial was conducted in Taiwan in 15- to 18- month-old healthy children to study the reactogenicity and immunogenicity of live varicella vaccine combined with standard measles-mumps-rubella vaccine. A total of 118 varicella antibody-negative children were enrolled. They received one dose of varicella vaccine and one dose of measles-mumps-rubella vaccine at the same time. The vaccines were well tolerated; adverse reactions were mild and infrequent, with 2% of vaccinees developed skin rash. No vesicular rash was seen. Concomitant varicella vaccination did not significantly increase the incidences of reactions associated with MMR vaccine. The seroconversion rates to varicella, measles, mumps and rubella all approached 100%. This study confirmed that simultaneous administration of live attenuated varicella vaccine and MMR vaccine was safe and immunogenic in healthy young children in Taiwan.

並列關鍵字

varicella-zoster virus ； vaccine ； measles ； mumps ； rubella