- 期刊
Clinical Aspects of the Hemolytic Uremic Syndrome
溶血性尿毒症候群之臨床觀察
摘要
溶血性尿毒症候群在臨床上分兩型，典型的病人有腹瀉的前驅症候，而且常和大腸杆菌O157有關，非典型的病人則沒有腹瀉的前驅症狀。然而，溶血性尿毒症候群在並不常見。爲了評估深谷溶血性尿毒症候群在小孩發病的臨床病程、後遺症就結果，同時也爲了了解造成死亡的危險因子，我們把過去間七個病人的資料做回顧性的整理及研究，這些病人中六位是男性，年齡從八個月大到三歲大。他們都沒有腹瀉的前驅症狀。而都有急性腎衰竭、高血壓及肝功能異常。一半的病人都出現過腦中風及抽痙，而且都有神經上的後遺症，兩個病人後來進展至末期腎病，有一個病人髮生急性呼吸窘迫症候群，兩位病人最後死亡。以上結果顯示末期腎病尤其合併急性呼吸窘迫症候群時，是死亡的危險因子。
並列摘要
Hemolytic uremic syndrome (HUS) can be clinically classified into two types: typical cases with a diarrheal prodrome of association with E. coli O157, and atypical cases without antecedent diarrhea. However, HUS is not common in Taiwan. To evaluate the clinical course, complications and outcome of HUS in children, and to identify the risk factors for mortality, retrospectively, seven cases of HUS in our hospital in the past 6 years were studied. Six of them were boys, and one was a girl. Their ages ranged from 0.67 to 3 years. None of them were preceded by diarrheal prodrome. Acute renal failure, hypertension and liver involvement were noted in all cases. Stroke and seizure developed in three of the cases with sequelae. Two cases progressed into end-stage renal disease (ESRD). One case developed acute respiratory distress syndrome (ARDS). Two cases (28.5%) expired. ESRD especially associated with ARDS was highly related to mortality.
延伸閱讀
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