香菇柄水萃物改善糖尿病降低阿茲海默氏症罹病風險初探

Preliminary Study of Lentinus edodes Stipe Extracts on Reducing the Risk of Alzheimer's Disease in Diabetic Animal Model

楊淑惠(Shu-Hui Yang) ； 楊惠婷(Hui-Ting Yang) ； 蔣淑琦(Shu-Chi Chiang)

《台灣農業研究》 67卷4期 (2018/12) Pp. 355-364

https://doi.org/10.6156/JTAR.201812_67(4).0004

摘要

阿茲海默氏症（Alzheimer's disease; AD）為慢性神經性退化疾病，本研究以糖尿病（diabetes mellitus; DM）誘發AD之動物模式，探討攝食香菇柄水萃物對AD危險因子的改善功效。研究顯示，大鼠攝食高脂飲食和注射低劑量Streptozotocin，確實造成類似糖尿病，多食、多喝及體重減輕的病徵，也引發AD危險因子數量的增加。DM大鼠攝食高劑量香菇蕈柄萃取物，可以有效改善血液生化值，增加胰島素分泌及腦部胰島素接受器的含量（P ＜ 0.05），而顯著降低腦部AD危險因子類澱粉前驅蛋白（amyloid precursor proteins; APP）、β-類澱粉蛋白-42（β-amyloid-42; Aβ42）)、β-分泌酶（β-site amyloid precursor protein cleaving enzyme 1; BACE1）、糖化終產物（advanced glycation endproducts; AGEs）、腫瘤壞死因子-α (tumor necrosis factor-α; TNF-α) 含量 (P＜ 0.05)。攝食香菇柄水萃物DM大鼠，進入十字迷宮開放手臂區和中心區的時間顯著增加（P ＜ 0.05）。由以上結果顯示，糖尿病動物攝食香菇柄水萃物可以改善糖尿病的生化代謝，進而降低AD罹病機率，或延緩後續病程發生。

關鍵字

香菇柄水萃物 ； 糖尿病 ； 阿茲海默氏症 ； 胰島素 ； 舉臂式十字迷宮

並列摘要

Alzheimer's disease (AD) is a chronic neurodegenerative disease. In this study, animal model of diabetes induced AD was studied to investigate the effect of Lentinus edodes stipe extracts (LedoStE) on improving the risk factors of AD. Resultss showed that rats fed a high-fat diet and injected low-dose streptozotocin did cause diabetes-like symptoms-eating more, drinking more and weight loss, and also led to increase of AD risk factors. Diabetes mellitus (DM) rats fed with high-dose LedoStE can effectively improve the blood parameter as well as increase insulin secretion and insulin receptor content of brain (P ＜ 0.05), while significantly decreased the levels of AD risk factors sash as amyloid precursor proteins (APP), β-amyloid-42 (Aβ42), β-site amyloid precursor protein cleaving enzyme 1 (BACE1), advanced glycation endproducts (AGEs), and tumor necrosis factor-α (TNF-α) (P ＜ 0.05) in brain. It also significantly increased the time (P ＜ 0.05) to enter the open and central areas of the elevated plus-maze in DM rats taking LedoStE. From the above results, it shows that diabetic animals intake LedoStE can improve the biochemical metabolism of diabetes, which may reduce the risk of Alzheimer's disease or delay the AD onset.

並列關鍵字

Lentinus edodes stipe extracts ； Diabetes mellitus ； Alzheimer's disease ； Insulin ； Elevated plus-maze