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淺談子宮內膜癌

Overview of Endometrial Cancer

摘要


子宮內膜癌是常見的婦科癌症,也是台灣女性十大癌症的第六位。危險因子包含:肥胖、長期使用雌激素製劑、糖尿病、高血壓、沒有生育、初經較早、停經較晚、與使用諾瓦得士錠(tamoxifen)。不正常的子宮出血是最主要的徵象,而大多數的子宮內膜癌婦女被診斷為疾病早期。手術治療是早期患者最主要的醫療處置,幸運的是,子宮內膜癌死亡率相對低,且五年存活率達81%。癌症治療後常伴隨合併症產生,如:不孕、手術性停經、下肢水腫、性功能障礙、焦慮與疲憊的現象,而這些合併常會影響婦女的生活品質。生活型態的改變,如:增加身體活動度及蔬果類食物的攝取,可以協助減緩合併症的症狀產生,並提升子宮內膜癌婦女的生活品質。

並列摘要


Endometrial cancer is the most common gynecological cancer and the sixth most common cancer among women in Taiwan. Risk factors for endometrial cancer include obesity, long-term estrogen replacement therapy, diabetes mellitus, hypertension, nulliparty, early age at menarche, late age at menopause, and tamoxifen therapy. Most women with endometrial cancer exhibit abnormal uterine bleeding. Endometrial cancer is often diagnosed at stage I. Surgery alone is the primary treatment for stage I endometrial cancer. Fortunately, mortality rates for endometrial cancer are relatively low, with a 5-year survival rate of 81% among women who are diagnosed with endometrial cancer in Taiwan. However, the common side effects of treatment, including infertility, surgical menopause, lymphedema of the lower extremities, sexual dysfunction, distress, and fatigue, impact significantly on the quality of life of patients. Lifestyle changes such as keeping physically active and eating a diet that is high in fruit and vegetables may alleviate symptoms and improve quality of life in women who have undergone treatment for endometrial cancer.

參考文獻


Andrews, S., & von Gruenigen, V. E. (2013). Management of the late effects of treatments for gynecological cancer. Current Opinion in Oncology, 25(5), 566–570. doi:10.1097/CCO.0b013e328363e11a
Bae, H. S., Lim, M. C., Lee, J. S., Lee, Y., Nam, B. H., Seo, S.-S., … Park, S.-Y. (2016). Postoperative lower extremity edema in patients with primary endometrial cancer. Annals of Surgical Oncology, 23(1), 186-195. doi:10.1245/s10434-015-4613-1
Bandera, C. A. (2005). Endometrial cancer in the hereditary nonpolyposis colorectal cancer syndrome. In G. Coukos & S. C. Rubin (Eds.), Cancer of the uterus (pp. 35-51). New York, NY: Marcel Dekker. doi:10.1201/b14149-3
Barakat, R. R., Bundy, B. N., Spirtos, N. M., Bell, J., & Mannel, R. S. (2006). Randomized double-blind trial of estrogen replacement therapy versus placebo in stage I or II endometrial cancer: A gynecologic oncology group study. Journal of Clinical Oncology, 24(4), 587–592. doi:10.1200/JCO.2005.02.8464
Bygdeman, M., & Swahn, M. L. (1996). Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women. Maturitas, 23, 259–263. doi:10.1016/0378-5122(95)00955-8

被引用紀錄


陳慧萱、林岑薰、高綺吟(2022)。運用舒適理論於一位子宮內膜癌末期病人之護理經驗腫瘤護理雜誌22(2),103-113。https://doi.org/10.6880/TJON.202212_22(2).08
游淑幀、葉惠玲(2022)。一位轉移性子宮內膜癌自殺病人之重症照護經驗長庚護理33(3),112-120。https://doi.org/10.6386/CGN.202209_33(3).0010
蔡岸圻(2010)。抗癌藥物 Moscatilin, Denbinobin 與 CHM-1對於血管新生抑制作用機轉之探討〔博士論文,國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2010.10664
陳冠學 (2013). 雙酚A 透過microRNA 調控影響人類子宮內膜癌細胞之基因表現 [master's thesis, National Tsing Hua University]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0016-2211201316552457

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