The question of San-Chiao with or without a substantial organ in physiology was disputed from historical physicians to recent scholars. This pending problem has been hung on for two thousands years, and it is a problem of the dissecting physiology in Chinese medicine urgently in need of solving. Because every organ and system has its unique physiological function and each physiological function has its corresponding organ. Between organ and physiology existed a relationship of body and function according modern medicine. The purpose of study is to survey San-Chiao hypothesis with name and shape wrote by historical and recent medical scholars included bladder-like theory, cavity sporangium theory, diaphragm and omentums theory, membrane type theory, lymph system theory and sympathetic trunk theory. Results suggest that the six hypothesis incompletely fitted definitions of San-Chiao functions confirmed by Nei-Jing, NanJing and Zhong Zang-Jing.