大柴胡湯對高脂飲食致大鼠非酒精性脂肪肝及高脂血症之療效評估

Therapeutic Effect of Da-Chai-Hu-Tang on Rat Model of Non-Alcoholic Fatty Liver and Hyperlipidemia by a Fat-Rich Diet

林臻偉(Chen-Wei Lin) ； 陳明和(Ming-Ho Chen) ； 王穩創(Wen-Chuang Wang) ； 謝小燕(Hsiao-Yen Hsieh) ； 陳榮洲(Jung-Chou Chen)

《中西整合醫學雜誌》 8卷1期 (2006/12) Pp. 1-11

https://doi.org/10.29613/JICWM.200612.0001

摘要

非酒精性脂肪肝炎(Non-alcoholic steatohepatitis, NASH)是一種慢性肝炎，其肝組織病理學變化與酒精性脂肪性肝炎(Alcoholic steatohepatitis, ASH)相似，兩者的分别在於病人的明確飲酒史。NASH的主要危險因素有肥胖、第Ⅱ型糖尿病、血脂肪過高或急慢性肝炎等。絕大多數NASH息者有肥胖現象，因此本實驗選擇以高脂飲食誘發NASH及高脂血症之大鼠模型為研究對象，以評估中藥大柴胡湯對NASH及高脂血症的治療成效。近年來中醫臨床治療脂肪肝的報導日益增多，大柴胡湯更是經常被使用的中藥方劑並在臨床被證實有效，但仍缺乏正式的研究來證實。本研究的目的在於探討大柴胡湯，在高脂飲食所致之非酒精性脂肪性肝炎大鼠模型中，是否有預防的效果，同時進一步探討中藥的作用機制。研究結果顯示，經高脂飲食餵養8週，確實能誘發實驗大鼠之脂肪變性，而大柴胡湯在以14gm/kg/day的劑量時，能預防造模動物之高膽固醇血症及肝臟中央靜脈區之發炎現象，其治療機理則待進一步證實。

關鍵字

高脂飲食 ； 大柴胡湯 ； 非酒精性脂肪肝 ； 高脂血症

並列摘要

Non-alcoholic steatohepatitis(NASH) is the chronic hepatitis that its pathological findings are similar to the change of alcoholic steatohepatitis(ASH) with steatonecrosis; the distinction between alcoholic and nonalcoholic forms of steatohepatitis is based on patient history of drinking. Certain groups of persons are recognized as having an increased prevalence of NASH, in particular those with obesity or diabetes mellitus. There is, however, less information available about the pathogenesis and treatment of this disorder than about its epidemiology. In this study, we used Traditional Chinese formula Da-Chai-Hu-Tang(DCHT) to treat rat model of non-alcoholic fatty liver disease and hyperlipidemia by a fat-rich diet for eight weeks, and compared its efficacy according to pathological findings. Results demonstrated that the rat model of steatosis can be established by feeding of fat-rich diet for eight weeks, and hypercholesterolemia can be prevented by treating DCHT with 14gm/kg/day.

並列關鍵字

Fat-Rich Diet ； Da-Chai-Hu-Tang ； Non-alcoholic Fatty Liver ； Hyperlipidemia