The goal of the project was to examine current issues in the field of pesticide exposure assessment with the aim of reaching an international harmonized approach to methods of exposure assessment and pesticide safe use and protection from pesticide application. Collected 1994-2003 local 326 generic pesticide exposure data of 9 years with 5 different sprayer equipment and 16 different crop pesticide application in Taiwan. On the basis of this assumption, modeling of worker exposure has been suggested as a basis for the estimation of surrogate or generic data that may be used in a first step for risk assessment. These results showed that Percentages of the toxic dose per hour (PTDPHs) of pesticides of less than 1% should be safe. PTDPHs including both dermal and inhalation exposure were used to evaluate the acute risk assessment of the 5 kinds of application equipment. Margin of Safety (MOS) values were evaluated for chronic risk assessment with 6 h of applied. MOS values lower than 1 should be a source of concern.