In March 1997, an outbreak of foot-and-mouth disease (FMD) in pigs occurred in southern Taiwan. The infected sows developed vesicles, erosion, ulceration, or crusts on the snouts, lips, coronary bands, teats, and udder. The affected piglets had similar cutaneous lesions to those seen in the sows and tiger heart which contained degenerative and necrotic myocardial fibers. A virus was isolated from the affected pigs and was identified as FMD virus by the Institute of Animal Health, Pirbright, England. Neither clinical signs nor lesions were found in other cloven-hoofed animals in the island.