甲氧基護谷與2，4-地除草劑誘發大鼠子代外觀、細部骨路及內臟異常性評估

The Effects of the Herbicide Chlormethoxynil and 2, 4-D on External, Skeletal and Visceral Anomalies of Fetuses in Rats

呂水淵(Shui-Yuan Lu) ； 王順成(Shun-Cheng Wang)

《中華民國獸醫學會雜誌》 24卷1期 (1998/03) Pp. 29-41

https://doi.org/10.7009/JTCSVS.199803.0029

摘要

以胃管投藥法探討甲氧基護谷（chlormethoxynil）及2，4-地（2，4-Ｄ）兩種本省常用除草劑其潛在致子鼠外觀、細部骨骼與內臟異常之影響。試驗結果顯示，兩藥劑在測試劑量下，均未引起子鼠外觀畸形（external malformation）。在誘發子鼠細部骨骼異常（skeletal variation and malformation）方面，甲氧基護谷藥劑可造成子鼠頭顱窗門張大、胸骨小於6根、胸骨異常或發育不全、肋骨融合、波浪狀肋骨或肋骨異常及啞鈴狀胸椎中心等症狀；2，4-地藥劑使子鼠形成頭顱窗門張大、胸骨異常或發育不全、波浪狀肋骨或肋骨異常及啞鈴狀胸椎中心等現象。就子鼠之內臟異常（visceral variation and malformation）而言，甲氧基護谷及2，4-地均可造成氣管不規則、腎臟左右大小不一、腦積水與腦室異常及大腦兩側大小不一及咽裂等異常；此外，甲氧基護谷藥劑另可產生胸腺分裂。兩藥劑所造成之子鼠畸形均屬輕度畸形性。

關鍵字

甲氧基護谷 ； 2,4-地 ； 外觀畸形 ； 骨骼畸形 ； 內臟異常

並列摘要

This study evaluated the teratologic effects as external, visceral, and skeletal examinations of fetus in rats. The test was administered by a gavage with the chlormethoxynil and2, 4-D. Experimental/ Analysis results did not detect any external malformations in the two herbicides. However, these herbicide-treated rats contained common skeletal anomalies and variations such as large open fontanelle, number of the sternal ＜ 6, hypoplastic or split sternal, fused ribs, wavy ribs, dumbell-shaped thoracic center. In addition, among the visceral defects in the herbicides included irregular trachea, side-weighed kidney, enlarged brain ventricles, and cleft pharynx. Split thymus was found only in chlomethoxynil. Based on the results presented herein, we can conclude that chlormethoxynil and 2,4-0 are weakly teratogenic agents in rats.

並列關鍵字

Clormethoxynil ； 2, 4-D ； External malformation ； Skeletal abnormality ； Visceral abnormality