The paper has first outlined a few uncertainties associated with the quantitative estimation of the future global climate change. The definitions of the radiative forcing and the global warming potential are introduced. Then, the discussions are focused on the effects of tropospheric ozone and aerosols. Generally, the uncertainties associated with the tropospheric ozone are mainly with the uncertain future increasing trend of tropospheric ozone amount, which could be resulted from the atmospheric transport and the complicate photochemical reactions. As to the uncertainties associated with the tropospheric aerosols, there are troubles in determining the size spectra, chemical composition, optical properties, spatial distribution of aerosols, and the could physical properties after aerosols turning to be CCNs. In all, research to clear the discussed uncertainties in Taiwan region are proposed.