An important consideration of a tissue paper mill design and operation is to treat mill effluents so that their impact on the environment is minimal and eventually non-polluting. Fiber and chemicals such as hemi-celluloses, wet strength agent, retention aids and dispersants are the main contaminants in the effluents, which result in COD loading in a small-sized Taiwan tissue paper mill. While maintaining the paper strength and softness of tissue paper, with the addition of less than 2%(on o.d. pulp) cationic epoxy resin-treated calcium carbonate in stock where cationic CaCO_3 can absorb some chemical additives on the fiber surface. By doing so, it is an efficient way for the pollutant removal, thus reducing the COD level below 100ppmin effluents that will meet the requirements of Taiwan Environmental Protection Standard (<100 ppm) for a small-sized tissue paper mill in Taiwan.