- 期刊
利用氣相層析法測定Metoclopramide及其類似物Bromopride
Determination of Metoclopramide and Its Analogue, Bromopride by Gas Liquid Chromatography
摘要
Metoclopramide及Bromopride為不同之鹵素取代於苯環上之類似物(analogue)。該二成分難以紫外光分光光度法分辨：而薄層分析法亦尚待研討。今以氣相層析法用6'×1/4”×2mm，3% SE-30 on Chromosorb W HP (80~100Mesh)或5% OV-17 on Chromosorb W HP火焰離子化偵測器(FID)鑑別定量此二成分，其回收率分別達99.5%及97.2%，簡便且精確，並可應用於含各該成分之口服製劑及注射劑。
並列摘要
Both Metoclopramide and Bromopride are halogeno analogues. They can not be differentiated easily by thin layer chromatography and their UV absorption spectrums. Separation and determination of these two analogues have been developed by gas liquid chromatography with 6'×1/4”×2mm, 3% SE-30 on chromosorb W HP or 5% OV-17, Flame Ionization Detector. This method is simple and reliable and applied successfully for the analysis of individual analog in tablets and injections.
並列關鍵字
無資料延伸閱讀
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