複方製劑中Tolnaftate定量法之比較

Comparison on the Assays of Tolnaftate in Pharmaceutical Compound Preparations

周秀冠(Shou-Guan Chou) ； 徐廷光(Ting-Guang Shyu) ； 謝彭生(Peng-Sheng Hsieh)

《藥物食品檢驗局調查研究年報》 3號 (1985/09) Pp. 47-52

https://doi.org/10.6946/ASRNL.198509.0047

摘要

Tolnaftate在分別與Benzocaine，Hexachlorophene，Salicylic acid，Methyl salicylate等成分配合之複方外用製劑中，其定量方法有：(1)紫外光吸光度測定法＾1，(2)可視光吸光度測定法＾2，(3)高效液相層析法＾3。經研討比較，其中仍以高效液相層析法最為便捷、實用。

關鍵字

Tolnaftate ； Benzocaine ； 複方製劑 ； 紫外光吸光度法 ； 可視光吸光度法 ； 高效液相層析法

並列摘要

In preparations for external use, tolnafate is usually formulated with benzocaine, hexachlorophene, salicylic acid, and methyl salicylate, respectively. Determination of Tolnaftate in these preparations can be performed by UV spectrophotometric method, colorimetric analysis, and high performance liquid chromatography. From the comparison on the above methods, the results indicate that determination of Tolnaftate by high performance liquid chromatography is simpler and more practical.