化粧品皮膚過敏反應試驗與衛生化學檢查

The Test of Skin Irritation and Hygineic Chemists for Cosmetics

曾信雄(Hshinn-Hshiung Tseng) ； 陳苾芬(Bi-Fen Chen) ； 林祖煌(Tsu-Huang Lin)

《藥物食品檢驗局調查研究年報》 7號 (1989/09) Pp. 25-28

https://doi.org/10.6946/ASRNL.198909.0025

摘要

本試驗是以價購方式自台灣區北、中、南、東部等地區抽購市售之面霜化粧品類，並且參照Draize氏貼布試驗方法與判定標率，將家兔受刺激程度的輕重區分為喜刺激性、輕微刺激性、中度刺激性及嚴重刺激性等四級。試驗結果刺激性陽性者則進行一般衛生化學檢查，分析其檢體中是否含汞塩，Bithionol或Hydroquinone Monobenzyl Ether等。
尚試驗結果顯示154件檢體中判定為無刺激性者71件(46.1%)，輕微刺激性者41件(26.6%)，中度刺激性者42件(27.3%)，然並未發現具有嚴重刺激性反應者。其中83件具有刺激性反應之檢體，經一般衛生化學檢查結果發現9件含有汞鹽(10.8%)，但所有檢體均不含Bithionol及Hydroquinone Monobenzyl Ether。

關鍵字

刺激性試驗 ； 衛生化學檢查

並列摘要

Samples for the study are face-dressing cosmetics which were bought from northern, middle, southern and eastern area of Taiwan. The method of Draize's Patch Test was followed.
According to the criteria of judgement for irritation, the severity of symptoms of skin irritation is divided into four classes: no, mild, moderate and severe irritation. The samples showing positive reactions were further analyzed to check if their ingredients containing mercury, bithionol or hydroquinone monobenzyl ether.
The results show that among the 154 samples, 71 are no irritation (46.1%), 41 mild irritation (26.6%), 42 moderate irritation (27.3%) and no case of severe irritation was found. The samples of 83 positive irritation were further analyzed. It was found that 9 samples contained mercury and no bithionol and hydroquinone monobenzyl ether were found.

並列關鍵字

irritation test ； hyginic chemists test