- 期刊
Endothelium-Dependent Higenamine-Induced Aortic Relaxation in Isolated Rat Aorta
並列摘要
The pharmacological action of higenamine in isolated rat aorta was investigated. Although the beta-adrenoceptor antagonist propranolol(1×10^(-5)M) completely blocked the beta-adrenoceptor agonist higenamine in inducing a positive chronotropic activity in isolated mouse atria, the higenamine-induced aortic relaxation was not completely antagonized by this concentration of propranolol. The present data also demonstrate that the higenam-ineinduced aortic relaxation was attenauted in the absence of endothelium. These findings suggest that the beta-adrenoceptor specificity to higenamine in aorta is different from that of beta-1 in atria; moreover, the beta-adrenoceptors sensitive to higenamnine are mainly located in the endothelial layer.
延伸閱讀
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