- 期刊
高雄市B型肝炎流行病學研究
A Study on the Epidemiology of Hepatitis B in Kaohsiung City
摘要
Employing a Multi-stage sampling method, serum samples of 4081 Kaohsiung citizens from I to 86 years old were examined for hepatitis B surface antigen and hepatitis B core antibody with enzyme immuno-assay and for c-fetoprotein on those over 40 years of age. We found that the HBsAg positive rate was 22.03% (899/4081) and the anti-HBc positive rate was 85.9% (3506/4081). AFP levels were more than 15μg/ml in 1.09% (15/1382), and glutamic pyramic transaminase (GPT) activities were more than 35 IU in 6.4% (262/4081). One hundred and sixty eight with abnormal GPT or AFP received ultrasonographic examination. 37.5%(63/168) were ultrasonically abnormal including fatty liver in 38, hepatitis in 15, liver tumor in 3, cholecystolithiasis in 4, liver cyst in 1, and liver cirrhosis in 2. The age-adjusted HBsAg positive rate was 23.87% in males and 20.17% in females, the difference was statistically significant (p＜0.01). The anti-HBc positive rate in males was 85.1% and 84.52% in females, the difference was not statistically significant. The anti-HBc positive rate had a tendency to increase with age. The age-adjusted HBsAg positive rate of all districts showed the highest to be 34.79% in Ku-shan district with 16.18% in Hsin-hsing district as the lowest. The percentage of children aged 1-4 years with anti-HBc was as high as 62.4%. Therefore, the infection rate of hepatitis B virus in children in Kaohsiung city was high, and the facts called for the successful implementation of a hepatitis B vaccination program. The GPT values of HBsAg-positive males younger than 40 years old were high, whether this is related to later development of hepatocellular carcinoma is unknown and needs further study.
關鍵字
無資料並列摘要
Employing a Multi-stage sampling method, serum samples of 4081 Kaohsiung citizens from I to 86 years old were examined for hepatitis B surface antigen and hepatitis B core antibody with enzyme immuno-assay and for c-fetoprotein on those over 40 years of age. We found that the HBsAg positive rate was 22.03% (899/4081) and the anti-HBc positive rate was 85.9% (3506/4081). AFP levels were more than 15μg/ml in 1.09% (15/1382), and glutamic pyramic transaminase (GPT) activities were more than 35 IU in 6.4% (262/4081). One hundred and sixty eight with abnormal GPT or AFP received ultrasonographic examination. 37.5%(63/168) were ultrasonically abnormal including fatty liver in 38, hepatitis in 15, liver tumor in 3, cholecystolithiasis in 4, liver cyst in 1, and liver cirrhosis in 2. The age-adjusted HBsAg positive rate was 23.87% in males and 20.17% in females, the difference was statistically significant (p＜0.01). The anti-HBc positive rate in males was 85.1% and 84.52% in females, the difference was not statistically significant. The anti-HBc positive rate had a tendency to increase with age. The age-adjusted HBsAg positive rate of all districts showed the highest to be 34.79% in Ku-shan district with 16.18% in Hsin-hsing district as the lowest. The percentage of children aged 1-4 years with anti-HBc was as high as 62.4%. Therefore, the infection rate of hepatitis B virus in children in Kaohsiung city was high, and the facts called for the successful implementation of a hepatitis B vaccination program. The GPT values of HBsAg-positive males younger than 40 years old were high, whether this is related to later development of hepatocellular carcinoma is unknown and needs further study.