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Acyclic Nucleosides Part3: Synthesis of Certain 1-[(1,3-Dihydroxy-2-propoxy)methy1]6-azauracils as Potential Antiviral Agents

裂環核? 第三報:抗病毒潛能1-[(1,3-Dihydroxy-2-propoxy)methy1]6-azauracils 之合成

並列摘要


The preparation of certain 1-[(1,3-Dihydroxy-2-propoxy) methy1] 6-azauracils, acyclic analogues of antiviral DHPG, is described. A number of 6-azauracils were trimethylsilylated and then coupled with 2-chloromethoxypropane to give 1-[(1,3-Dihydroxy-2-propoxy) methy1] 6-azauracils which were debenzylated with either boron trichloride or palladium oxide to yield the title compounds.

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