- 期刊
Synergistic Activities of Combinations of Antibiotics against Methicillin-Resistant Staphylococcus Aureus
抗生素對Methicillin耐性金黃色葡萄球菌〈MRSA〉的協同作用之檢討
摘要
近年來，methicillin-resistant staphylococcus aureus〈 MRSA〉經常從醫院的檢體中被分離，而且 MRSA所引起的感染症也在增加中，在臨床治療上已成為一個重大的問題。 本研究的材料是由醫院中分離所得的MRSA，共62菌株，然後我們利用微量液體稀釋法來分析，檢討vancomycin-minocycline, vancomycin-cefamandole, vancomycin-fosfomycin, cefamandole-minocycline和cefamandole-fosfomycin的協同作用的情形，由其結果可判定協同作用〈FIC index≦0.5〉的菌株，分別為vancomycin-minocycline有4菌株〈6.4%〉，vancomycin-cefamandole有52菌株〈84%〉，vancomycin-fosfomycin有13菌株〈20.9%〉，cefamandole-Minocycline有12菌株〈19.3%〉和cefamandole-fosfomycin有62菌株〈100%〉，再根據平均FIC indices的方法來計算，可知vancomycin-minocycline是1.50, vancomycin-cefamandole是0.39, vancomycin-fosfomycin是0.64，cefamandole-minocycline是0.85和cefamandole-fosfomycin是0.25。這次對於MRSA菌株的抗生素協同作用檢討的結果cefamandole-fosfomycin的殺菌效果效率為最優越。
關鍵字
無資料並列摘要
The effect of an antibiotic combination against methicillin-resistant Staphylococcus aureus which is frequently found in hospitalized patients were investigated. By means of the microtiter checkerboard method, combinations of vancomycin-minocycline, vancomycin-cefamandole, vancomycin-fosfomycin, cefamandole-minocycline and cefamandole-fosfomycin were found to be synergistic against 6.4, 84.0, 20.9, 19.3 and 100.0% of the sixty-two strains tested, respectively. The means of the fractional inhibitory concentration (FIC) indices of vancomycin-minocycline, vancomycin-cefamandole, vancomycin-fosfmycin, cefamandole-minocycline and cefamandole-fosfomycin were 1.50, 0.39, 0.64, 0.85 and 0.25, respectively. Thus, the effect of the combination of cefamandole-fosfomycin was superior to other combinations.
延伸閱讀
- 黃樹樺（2004）。社區Oxacillin 抗藥性金黃色葡萄球菌感染或移生之流行病學分析〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2903200614014263
- Ho, Y. C. (2007). 利用聚合酶連鎖反應定量methicillin 抗藥性金黃色葡萄球菌血液中菌量並監測療效 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2007.02841
- Chen, S. Y. (2017). 發展急診病人抗藥性金黃色葡萄球菌與多重抗藥性格蘭氏陰性菌預測模式以預防抗藥性細菌於醫院內傳播 [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU201704129
- 陳麗婷、秦登峰、謝士明、林金絲（2002）。抗藥性金黃色葡萄球菌感染管制措施之探討。院內感染控制雜誌，12(5)，308-314。https://www.airitilibrary.com/Article/Detail?DocID=10262407-200210-12-5-308-314-a
- Wang, J. T., Lin, S. F., Chiu, H. L., Wang, L. C., Tai, H. M., Jiang, C. F., Chang, S. C., & Chu, S. H. (2004). 一教學醫院院內methicillin抗藥性金黃色葡萄球菌感染之分子流行病學與控制. Journal of the Formosan Medical Association, 103(1), 32-36. https://doi.org/10.29828/JFMA.200401.0005