以3例接受皮膚病理切片檢查之登革熱病人為中心,就皮疹之發生、消褪過程,皮膚病理變化,病變處血管及周圍浸潤細胞之超微細構造等做一探討。發現登革熱皮疹之主要病理變化為真皮上層微血管內皮細胞之變性、嗜中性白血球及紅血球之遊出。並推論內皮細胞之破壞與病毒上感染有關,而嗜中性白血球及紅血球之外溢則與內皮細胞之病變有密切之關係存在。
Evaluation of histopathological and ultrastructural changes in skin eruptions of three denque fever patients was performed. The main pathological findings in skin lesions were swelling of the endothelial cells in small vessels of papillary dermis, diapedesis of neutrophils, extravasation of erythrocytes and perivascular mononuclear cells infiltration. Ultrastructural observation revealed degeneration of endothelial cells and neutrophils. The relationships among endothelial cell damage, cell infiltration and hemorrhage were discussed.