Inhibitory Effects of Isoquinoline - Type Alkaloids on Leukemic Cell Growth and Macromolecule Biosynthesis

異喹啉類生物鹼對白血病細胞生長及巨型分子生合成之抑制效果

曾誠齊(Cherng-Chyi Tzeng) ； 吳永昌(Yang-Chang Wu) ； 蘇燦隆(Tsann-Long Su) ； Kyoichi A. Watanabe ； 盧盛德(Sheng-Teh Lu) ； 周廷潮(Ting-Chao Chou)

《The Kaohsiung Journal of Medical Sciences》 6卷2期 (1990/02) Pp. 58-65

https://doi.org/10.6452/KJMS.199002.0058

摘要

本論文係研究由台灣產植物分離之34種異哈喹類生物鹼，即benzyltetrahydroisoguino-lines.或其N-oxides, aporphines, oxoaphorph-ines以及1-N, N-dimethylaminoethylphe-nanthrenes或其N-oxides對抑制去氧核苷，想苷及氨基酸等分別組合為DNA，RNA及protein之效價加以評估。並研究其對老鼠白血病細胞L 1210以及兩種人體白血病細胞CCRF-CEM及HL-60之生長抑制活性。發現(±)-N-methylc-oclaurine(3)，(-)-norannuradhapurine HBr (19), oxoglaucine (23), dicentrine methane (27)及1-(N-methyl-N-hydroxy-aminoethyl)-3，4-methylenedioxy-7-methoxyphenanth-rene (28)具有小於10μM濃度之IC50。

並列摘要

A number of benzylisoquinoline alkaloids of plants indigenous to Taiwan were isolated and purified and their chemical structures were deter-mined. These compounds, namely benzyltetrahy droisoquinolines or their N-oxides, aporphines, oxoaporphines and 1-N, N-dimethylaminoethylphe-nanthrenes or their N-oxides, were studied for their potency in inhibiting precursor incorporation into DNA, RNA and protein. Inhibition of murine leukemic L1210 and human leukemic CCRF-CEM and HL-60 cell growth was also examined. Of the compounds evaluated fro cell growth inhibition, (±)-N-methylcoclaurine(3), (-)-norannuradhapurine HBr(19), oxoglaucine (23), dicentrine methane (27) and 1-(N-methyl-N-hydroxyaminoethyl)-3, 4-methylenedioxy-7-methoxyphenanthrene(28) showed an IC50＜10μM.

並列關鍵字

isoquinoline alkaloids ； human leukemic cells